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Erschienen am Beschreibung Autorenportrait Inhalt Informationen zu E-Books Wireless Cortical Implantable Systems examines the design for data acquisition and transmission in cortical implants. The first part of the book covers existing system level cortical implants, as well as future devices. The authors discuss the major constraints in terms of microelectronic integrations are presented. Contributor s : Schmid, Alexandre [author. Tags from this library: No tags from this library for this title. Total holds: 0.

Wireless Cortical Brain-Machine Interface for Whole-Body Navigation in Primates

Log in to your account to post a comment. Export Cancel. Share Facebook. The extraocular components are integrated into the frame of spectacles. Right , top : diagram shows the stimulator unit placed on the retinal surface.


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RU, receiver unit, which captures the incoming data and energy; MC, microcable, which connects receiver and stimulator unit; SU, stimulator unit microelectrode array , which acts as a flexible microcontact foil adherent to the retinal surface. F igure 2. At left is the artificial lens made of polydimethylsiloxane; PDMS with the receiver unit RU for data and energy transfer and the receiver microchip RC. At right is the stimulator unit SU consisting of a microchip integrating 25 individually programable current sources PCSs and a polyimide matrix with 25 microelectrodes connected with the receiver unit via a microcable MC.


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Bottom : photograph of implant substrate with the electrode array before assembly of the stimulator chip pad array on the right. For electrical stimulation, different inner electrode dots can be used as cathode and anode, or an inner dot and outer ring can be used as the electrode pair, respectively. F igure 3. Left : the receiver unit is shown in the anterior segment and the microelectrode array placed on the retinal surface arrow. Right : view of the transmitter coil in front of the surgical eye and the intraocular receiver unit. F igure 4. Optical imaging of the visual cortex after electrical stimulation of the inner retina with a completely implanted retinal prosthesis.

Cortical Activation Via an Implanted Wireless Retinal Prosthesis | IOVS | ARVO Journals

Top left : drawing and light micrograph outlining the left hemisphere with the region exposed for optical imaging. Bottom right : a schema of the electrodes overlying a fundus image taken directly after implantation of the telemetric device.

The electrode array dimly visible in the background was positioned mainly in the upper nasal hemiretina across the AC. Individual electrodes are numbered. The positions of the four electrode pairs used for stimulation are marked A, B, C, and D black : anodal poles; white : cathodal poles. Activation of the electrode pairs resulted in cortical activation as shown, respectively A - D.


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Dark areas : strongly active regions; light zones : less-active regions. Left : cortical activation appeared in a patchy fashion mainly in the left part of the imaged cortical region. Furthermore, the border between active and less active regions shifted according to the retinal stimulation site, in line with the visuotopic organization of the cortex. As the stimulation site moved farther lateral and downward in the retina, the activated cortical regions became more lateral and posterior.

For a better comparison, broken black lines denote the gradual shift of the border between active and less active regions. It is noteworthy that electrode pair D induced activation only in the most caudal part of the imaged region D. Middle : results of control recordings that were interleaved with the test conditions. In control experiments, optical images were acquired without electrical stimulation.

Right : cumulative gray-level distributions of image pixels summed along the anterior-posterior axis of activity images shown in A — D. Thick lines represent polynomial fits to the row data. Clearly, the position of peaks red bars along the latero-medial LM axis gradually shifted from medial to lateral as the activation site moved from A to D.

For electrode pair D, the retinotopic region was chiefly outside posterior to the imaged window; therefore, for the most part of the image only a weak response can be seen. Nevertheless, the corresponding peak stippled red line of the response field lies most laterally of all conditions. OD, optic disc; A, anterior; L, lateral. Initiation of impulses in visual cells of Limulus. J Physiol. The peripheral origin of nervous activity in the visual system. Mechanism of lateral inhibition in the eye of Limulus.

J Neurophysiol. The electrical stimulation of the retina by indwelling electrodes. Invest Ophthalmol Vis Sci. The patterns seen when alternating electric current is passed through the eye. Q J Exp Psychol. Morphometric analysis of macular photoreceptors and ganglion cells in retinas with retinitis pigmentosa. Arch Ophthalmol. Morphometric analysis of the extramacular retina from postmortem eyes with retinitis pigmentosa.

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Preservation of the inner retina in retinitis pigmentosa: a morphometric analysis. Visual perception elicited by electrical stimulation of retina in blind humans. Subretinal implantation of semiconductor-based photodiodes: durability of novel implant designs. J Rehabil Res Dev. Visual perception in a blind subject with a chronic microelectronic retinal prosthesis.

Introduction

Vision Res. Development of flexible stimulation devices for a retina implant system. Learning retina implants with epiretinal contacts. Ophthalmic Res. Functional architecture of cortex revealed by optical imaging of intrinsic signals. Retinotopic organization of areas 18 and 19 in the cat. J Comp Neurol. Micromachined, polyimide-based devices for flexible neural interfaces. Biomed Microdev. Microsystem integration techniques for intraocular vision prostheses using flexible polyimide-foils.

High density interconnects and flexible hybrid assemblies for active biomedical implants. Considerations on surface and structural biocompatibility as prerequisite for long-term stability of neural prostheses. J Nanosci Nanotech. In-vivo optical imaging of cortical architecture and dynamics. WindhorstU JohanssonH eds. Modern Techniques in Neuroscience Research. Springer Berlin.

Wireless Cortical Brain-Machine Interface for Whole-Body Navigation in Primates